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새로운 미래를 열어가는 원오믹스
논문
2022년
Jae Young Yoo., et al., Associations for Whole-exome Sequencing Profiling with Carcass Traits in Crossbred Pigs. , Korean Journal of Poultry Science
Yengo L., et al., A saturated map of common genetic variants associated with human height. Nature. 2022 Oct 12;. doi: 10.1038/s41586-022-05275-y
Ramdas S., et al., A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. Am J Hum Genet. 2022 Aug 4;109(8):1366-1387.
Kim JH., et al.,Clinical Manifestations and Genetic Analysis of 5 Korean Choroideremia Patients Initially Diagnosed With Retinitis Pigmentosa. J Korean Med Sci. 2022 Jan 17;37(3):e5.
2021년
Piao, X.M., et al., Collagen type VIalpha1 and 2 repress the proliferation, migration and invasion of bladder cancer cells. Int J Oncol, 2021. 59(1).
Goodrich., J.K., et al., Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nat Commun, 2021. 12(1): p. 3505.
Byun, Y.J., et al., Urinary microRNA-1913 to microRNA-3659 expression ratio as a non-invasive diagnostic biomarker for prostate cancer. Investig Clin Urol, 2021. 62(3): p. 340-348.
Jo HY., et al., Single-Cell RNA Sequencing of Human Pluripotent Stem Cell-Derived Macrophages for Quality Control of The Cell Therapy Product. Front Genet. 2021;12:658862.
Graham SE., et al.,The power of genetic diversity in genome-wide association studies of lipids. Nature. 2021 Dec;600(7890):675-679.
Lee I., et al.,. A Raf-like kinase is required for smoke-induced seed dormancy in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14).
2020년
Piao, X.M., et al., A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer. Oncol Lett, 2020. 19(1): p. 476-486.
Kim, S.M., et al., Transcriptome Profiling Associated with Carcass Quality of Loin Muscles in Crossbred Pigs. Animals (Basel), 2020. 10(8)
Kim, D., et al., Genetic Features of Lung Adenocarcinoma with Ground- Glass Opacity: What Causes the Invasiveness of Lung Adenocarcinoma? Korean J Thorac Cardiovasc Surg, 2020. 53(5): p. 250-257.
Piao, X.M., et al., A prognostic immune predictor, HLA-DRA, plays diverse roles in non-muscle invasive and muscle invasive bladder cancer. Urol Oncol. 2021 Apr;39(4):237.e21-237.e29.
2019년
Xu, Y., et al., Diagnostic value of combined IQGAP3/BMP4 and IQGAP3/FAM107A expression ratios in urinary cell-free DNA for discriminating bladder cancer from hematuria. Urol Oncol, 2019. 37(1): p. 86-96.
Piao, X.M., et al., Urinary cell-free microRNA biomarker could discriminate bladder cancer from benign hematuria. Int J Cancer, 2019. 144(2): p. 380-388.
Flannick, J., et al., Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature, 2019.
2018년
Lee, J.Y., et al., Identification of differentially expressed miRNAs and miRNA-targeted genes in bladder cancer. Oncotarget, 2018. 9(45): p. 27656-27666.
2017년
Zillikens, M.C., et al., Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun, 2017. 8(1): p. 80.
Manning, A., et al., A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes, 2017. 66(7): p. 2019-2032.
Flannick, J., et al., Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Sci Data, 2017. 4: p. 170179.
2016년
Lu, Y., et al., New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nat Commun, 2016. 7: p. 10495.
Lee, J.Y., et al., Aberrantly expressed microRNAs in the context of bladder tumorigenesis. Investig Clin Urol, 2016. 57 Suppl 1: p. S52-9.
Fuchsberger, C., et al., The genetic architecture of type 2 diabetes. Nature, 2016. 536(7614): p. 41-47.
Ehret, G.B., et al., The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet, 2016. 48(10): p. 1171-1184
2015년
Takeuchi, F., et al., Heterogeneous effects of association between blood pressure loci and coronary artery disease in east Asian individuals. Circ J, 2015. 79(4): p. 830-8.
Locke, A.E., et al., Genetic studies of body mass index yield new insights for obesity biology. Nature, 2015. 518(7538): p. 197-206.
Lim, N.K., et al., The Role of Genetic Risk Score in Predicting the Risk of Hypertension in the Korean population: Korean Genome and Epidemiology Study. PLoS One, 2015. 10(6): p. e0131603.
Kim, K., et al., High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. Ann Rheum Dis, 2015. 74(3): p. e13.
Kato, N., et al., Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet, 2015. 47(11): p. 1282-1293.
He, M., et al., Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Hum Mol Genet, 2015. 24(6): p. 1791-800.
2014년
Zhang, L., et al., Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet, 2014. 23(7): p. 1923-33.
Wen, W., et al., Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum Mol Genet, 2014. 23(20): p. 5492-504.
Replication, D.I.G., et al., Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet, 2014. 46(3): p. 234-44.
Pyun, J.A., et al., Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population. Menopause, 2014. 21(5): p. 522-9.
Moayyeri, A., et al., Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Hum Mol Genet, 2014. 23(11): p. 3054-68.
Kwak, S.H., et al., A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans. Hum Mol Genet, 2014. 23(16): p. 4433-42.
Kim, Y.D., et al., Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans. World J Gastroenterol, 2014. 20(26): p. 8592-8.
Jin, H.S., et al., The PARK2 gene is involved in the maintenance of pancreatic beta-cell functions related to insulin production and secretion. Mol Cell Endocrinol, 2014. 382(1): p. 178-89.
Heo, S.G., et al., Male-specific genetic effect on hypertension and metabolic disorders. Hum Genet, 2014. 133(3): p. 311-9.
Flannick, J., et al., Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat Genet, 2014. 46(4): p. 357-63.
Consortium, S.T.D., et al., Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature, 2014. 506(7486): p. 97-101.
Chen, P., et al., Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians. Diabetes, 2014. 63(7): p. 2551-62.
Bang, S.Y., et al., Targeted exon sequencing fails to identify rare coding variants with large effect in rheumatoid arthritis. Arthritis Res Ther, 2014. 16(5): p. 447.
2013년
Zheng, W., et al., Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet, 2013. 22(12): p. 2539-50.
Yim, D.H., et al., ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population. World J Gastroenterol, 2013. 19(35): p. 5870-6.
Yang, J., et al., Ubiquitous polygenicity of human complex traits: genome-wide analysis of 49 traits in Koreans. PLoS Genet, 2013. 9(3): p. e1003355.
Shi, J., et al., New breast cancer risk variant discovered at 10q25 in East Asian women. Cancer Epidemiol Biomarkers Prev, 2013. 22(7): p. 1297-303.
Park, T.J., et al., Genome-wide association study of liver enzymes in korean children. Genomics Inform, 2013. 11(3): p. 149-54.
Park, M.H., et al., Identification of a genetic locus on chromosome 4q34-35 for type 2 diabetes with overweight. Exp Mol Med, 2013. 45: p. e7.
Oh, J.H., et al., Genotype instability during long-term subculture of lymphoblastoid cell lines. J Hum Genet, 2013. 58(1): p. 16-20.
Moon, S., et al., KGVDB: a population-based genomic map of CNVs tagged by SNPs in Koreans. Bioinformatics, 2013. 29(11): p. 1481-3.
Ma, R.C., et al., Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. Diabetologia, 2013. 56(6): p. 1291-305.
Lee, J.Y., et al., A genome-wide association study of a coronary artery disease risk variant. J Hum Genet, 2013. 58(3): p. 120-6.
Kim, Y.K., et al., Gene-based copy number variation study reveals a microdeletion at 12q24 that influences height in the Korean population. Genomics, 2013. 101(2): p. 134-8.
Kim, H.N., et al., Genome-wide association study of the five-factor model of personality in young Korean women. J Hum Genet, 2013. 58(10): p. 667-74.
Kelly, T.N., et al., Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci. Hypertension, 2013. 62(5): p. 853-9.
Ichihara, S., et al., Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis. Circ Cardiovasc Genet, 2013. 6(6): p. 569-78.
Hwang, J.Y., et al., Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture. J Med Genet, 2013. 50(4): p. 212-9.
Hwang, J.Y., et al., Recapitulation of previous genome-wide association studies with two distinct pathophysiological entities of gastric cancer in the Korean population. J Hum Genet, 2013. 58(4): p. 233-5.
Go, M.J., et al., New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. J Hum Genet, 2013. 58(6): p. 362-5.
Franceschini, N., et al., Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet, 2013. 93(3): p. 545-54.
Eom, S.Y., et al., Dietary aflatoxin B1 intake, genetic polymorphisms of CYP1A2, CYP2E1, EPHX1, GSTM1, and GSTT1, and gastric cancer risk in Korean. Cancer Causes Control, 2013. 24(11): p. 1963-72.
Consortium, C.A.D., et al., Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet, 2013. 45(1): p. 25-33.
2012년
Yoon, D., et al., Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. Hum Genet, 2012. 131(6): p. 1009-21.
Wen, W., et al., Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet, 2012. 44(3): p. 307-11.
Ro, M., et al., Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population. Scand J Immunol, 2012. 76(2): p. 151-7.
Pyun, J.A., et al., Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study. Genomics Inform, 2012. 10(2): p. 88-98.
Okada, Y., et al., Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nat Genet, 2012. 44(8): p. 904-9.
Kim, H.Y., et al., Association of ADIPOR1 polymorphisms with bone mineral density in postmenopausal Korean women. Exp Mol Med, 2012. 44(6): p. 394-402.
Kim, H.C., et al., A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study. Breast Cancer Res, 2012. 14(2): p. R56.
Kim, C., et al., Microarray-based mutation detection and phenotypic characterization in Korean patients with retinitis pigmentosa. Mol Vis, 2012. 18: p. 2398-410.
Hwang, J.Y., et al., Genome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition. J Hum Genet, 2012. 57(10): p. 660-4.
Hong, C.B., et al., BioSMACK: a linux live CD for genome-wide association analyses. BMB Rep, 2012. 45(1): p. 44-6.
Hong, C.B., et al., KAREBrowser: SNP database of Korea Association REsource Project. BMB Rep, 2012. 45(1): p. 47-50.
Go, M.J., et al., Effect of genetic predisposition on blood lipid traits using cumulative risk assessment in the korean population. Genomics Inform, 2012. 10(2): p. 99-105.
Dastani, Z., et al., Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet, 2012. 8(3): p. e1002607.
Cho, Y.S., et al., Genetics of type 2 diabetes in East Asian populations. Curr Diab Rep, 2012. 12(6): p. 686-96.
Bok, J., et al., Identification and extensive analysis of inverted-duplicated HBV integration in a human hepatocellular carcinoma cell line. BMB Rep, 2012. 45(6): p. 365-70.
2011년
Park, M.H., et al., Genome-wide SNP-based linkage analysis for ADNSHL families identifies novel susceptibility loci with positive evidence for linkage. Genes Genet Syst, 2011. 86(2): p. 117-21.
Park, M.H., et al., Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. J Med Genet, 2011. 48(1): p. 10-5.
Moon, S., et al., Data-driven approach to detect common copy-number variations and frequency profiles in a population-based Korean cohort. Eur J Hum Genet, 2011. 19(11): p. 1167-72.
Lee, E.J., et al., Genome-wide scan of granular corneal dystrophy, type II: confirmation of chromosome 5q31 and identification of new co-segregated loci on chromosome 3q26.3. Exp Mol Med, 2011. 43(7): p. 393-400.
Kim, Y.J., et al., Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet, 2011. 43(10): p. 990-5.
Kim, K.J., et al., Spectrum of rhodopsin mutations in Korean patients with retinitis pigmentosa. Mol Vis, 2011. 17: p. 844-53.
Kim, J.J., et al., A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease. Hum Genet, 2011. 129(5): p. 487-95.
Kim, B.J., et al., Association of Paraoxonase 1 (PON1) polymorphisms with osteoporotic fracture risk in postmenopausal Korean women. Exp Mol Med, 2011. 43(2): p. 71-81.
Kim, B.J., et al., Association of SMAD2 polymorphisms with bone mineral density in postmenopausal Korean women. Osteoporos Int, 2011. 22(8): p. 2273-82.
Kato, N., et al., Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet, 2011. 43(6): p. 531-8.
International Consortium for Blood Pressure Genome-Wide Association, S., et al., Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 2011. 478(7367): p. 103-9.
Fox, E.R., et al., Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet, 2011. 20(11): p. 2273-84.
Cho, Y.S., et al., Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet, 2011. 44(1): p. 67-72.
Chambers, J.C., et al., Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet, 2011. 43(11): p. 1131-8.
Cai, Q., et al., Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium. Hum Mol Genet, 2011. 20(24): p. 4991-9.
Bae, J.S., et al., The genetic effect of copy number variations on the risk of type 2 diabetes in a Korean population. PLoS One, 2011. 6(4): p. e19091.
Akula, N., et al., A network-based approach to prioritize results from genome-wide association studies. PLoS One, 2011. 6(9): p. e24220.
2010년
Yim, S.H., et al., Copy number variations in East-Asian population and their evolutionary and functional implications. Hum Mol Genet, 2010. 19(6): p. 1001-8.
Xu, S., et al., Genetic evidence supports linguistic affinity of Mlabri--a hunter-gatherer group in Thailand. BMC Genet, 2010. 11: p. 18.
Teslovich, T.M., et al., Biological, clinical and population relevance of 95 loci for blood lipids. Nature, 2010. 466(7307): p. 707-13.
Shu, X.O., et al., Identification of new genetic risk variants for type 2 diabetes. PLoS Genet, 2010. 6(9): p. e1001127.
Li, M.D., et al., Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population. PLoS One, 2010. 5(8): p. e12183.
Lee, H.J., et al., Fracture, bone mineral density, and the effects of calcitonin receptor gene in postmenopausal Koreans. Osteoporos Int, 2010. 21(8): p. 1351-60.
Lee, H.J., et al., Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in Koreans. Clin Chim Acta, 2010. 411(21-22): p. 1716-22.
Koo, B.K., et al., Polymorphisms of the reg1alpha gene and early onset type 2 diabetes in the korean population. Korean Diabetes J, 2010. 34(4): p. 229-36.
Kim, J.J., et al., Identification of 15 loci influencing height in a Korean population. J Hum Genet, 2010. 55(1): p. 27-31.
Kim, H.N., et al., Genetic variants that affect length/height in infancy/early childhood in Vietnamese-Korean families. J Hum Genet, 2010. 55(10): p. 681-90.
Hwang, J.Y., et al., Association of TWIST1 gene polymorphisms with bone mineral density in postmenopausal women. Osteoporos Int, 2010. 21(5): p. 757-64.
Hong, K.W., et al., Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and/or hypertension in two Korean cohorts. J Hum Hypertens, 2010. 24(6): p. 367-72.
Cho, S., et al., Joint identification of multiple genetic variants via elastic-net variable selection in a genome-wide association analysis. Ann Hum Genet, 2010. 74(5): p. 416-28.
Bae, J.S., et al., Identification of genome-wide copy number variations and a family-based association study of Avellino corneal dystrophy. Ophthalmology, 2010. 117(7): p. 1306-12 e4.
2009년
Park, M.H., Y. Kim, and J.Y. Lee, Identification of a novel HLA-DRB1 allele, HLA-DRB1*1217, in a Korean individual. Tissue Antigens, 2009. 73(6): p. 627-8.
Park, M., et al., Genetic associations of common deletion polymorphisms in families with Avellino corneal dystrophy. Biochem Biophys Res Commun, 2009. 387(4): p. 688-93.
Lee, H.J., et al., Association of a RUNX2 promoter polymorphism with bone mineral density in postmenopausal Korean women. Calcif Tissue Int, 2009. 84(6): p. 439-45.
Koh, J.M., et al., Association of IL-15 polymorphisms with bone mineral density in postmenopausal Korean women. Calcif Tissue Int, 2009. 85(5): p. 369-78.
Kim, T.H., et al., Polymorphisms in the Annexin gene family and the risk of osteonecrosis of the femoral head in the Korean population. Bone, 2009. 45(1): p. 125-31.
Kaput, J., et al., Planning the human variome project: the Spain report. Hum Mutat, 2009. 30(4): p. 496-510.
Hyun-Seok Jin, K.g.-W.H., Ji-Eun Lim , Gi•Ja Lee, Jong Ho Han, Min-jin Go, Jong-Young Lee, jeong-Taek Woo, Hun Kuk Park and Bermseok Oh, Association Analysis of v-AKT Murine Thymoma Viral Oncogene Homolog 1 (AKT1) PolymoIphisms and Type 2 Diabetes Mellitus in the Korean Population. GENES &. GENOMICS, 2009. 31(1): p. 73-83.
Hwang, J.Y., et al., HSD11B1 polymorphisms predicted bone mineral density and fracture risk in postmenopausal women without a clinically apparent hypercortisolemia. Bone, 2009. 45(6): p. 1098-103.
Hong, K.W., et al., RAPGEF1 gene variants associated with type 2 diabetes in the Korean population. Diabetes Res Clin Pract, 2009. 84(2): p. 117-22.
Hong, K.W., et al., Replication of the Wellcome Trust genome-wide association study on essential hypertension in a Korean population. Hypertens Res, 2009. 32(7): p. 570-4.
Consortium, H.P.-A.S., et al., Mapping human genetic diversity in Asia. Science, 2009. 326(5959): p. 1541-5.
Cho, Y.S., et al., A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet, 2009. 41(5): p. 527-34.
2008년
Park, M.H., et al., Allelic frequencies and heterozygosities of microsatellite markers covering the whole genome in the Korean. J Hum Genet, 2008. 53(3): p. 254-66.
Lee, E.J., et al., Association study between single nucleotide polymorphisms in the VEGF gene and polycystic ovary syndrome. Fertil Steril, 2008. 89(6): p. 1751-9.
Lee, E.J., et al., A novel single nucleotide polymorphism of INSR gene for polycystic ovary syndrome. Fertil Steril, 2008. 89(5): p. 1213-20.
Kim, T.H., et al., Genetic association study of polymorphisms in the catalase gene with the risk of osteonecrosis of the femoral head in the Korean population. Osteoarthritis Cartilage, 2008. 16(9): p. 1060-6
Kim, T.H., et al., Association of polymorphisms in the Interleukin 23 receptor gene with osteonecrosis of femoral head in Korean population. Exp Mol Med, 2008. 40(4): p. 418-26..
Kim, T., et al., Promoter polymorphisms of the vascular endothelial growth factor gene is associated with an osteonecrosis of the femoral head in the Korean population. Osteoarthritis Cartilage, 2008. 16(3): p. 287-91.
Dai, X.L., et al., Association analysis of tissue factor pathway inhibitor polymorphisms and haplotypes with osteonecrosis of the femoral head in the Korean population. Mol Cells, 2008. 26(5): p. 490-5.
2007년
Oh, B., et al., Associations of catalase gene polymorphisms with bone mineral density and bone turnover markers in postmenopausal women. J Med Genet, 2007. 44(1): p. e62.
Lee, H.J., et al., Polymorphisms and haplotypes of integrinalpha1 (ITGA1) are associated with bone mineral density and fracture risk in postmenopausal Koreans. Bone, 2007. 41(6): p. 979-86.
Koh, J.M., et al., Association of FLT3 polymorphisms with low BMD and risk of osteoporotic fracture in postmenopausal women. J Bone Miner Res, 2007. 22(11): p. 1752-8.
Koh, J.M., et al., Microphthalmia-associated transcription factor polymorphisms and association with bone mineral density of the proximal femur in postmenopausal women. Mol Cells, 2007. 23(2): p. 246-51.
Kim, Y., et al., A promoter nucleotide variant of the dendritic cell-specific DCNP1 associates with serum IgE levels specific for dust mite allergens among the Korean asthmatics. Genes Immun, 2007. 8(5): p. 369-78.
Kim, S.Y., et al., Association of KIT gene polymorphisms with bone mineral density in postmenopausal Korean women. J Hum Genet, 2007. 52(6): p. 502-9.
Kim, K.S., et al., Single nucleotide polymorphisms in bone turnover-related genes in Koreans: ethnic differences in linkage disequilibrium and haplotype. BMC Med Genet, 2007. 8: p. 70.
Kim, H.T., et al., Association analysis of sphingomyelinase 2 polymorphisms for the extrinsic type of atopic dermatitis in Koreans. J Dermatol Sci, 2007. 46(2): p. 143-6.
J. Min Lee, G.C.S., J.Y.Lee, Y.B.Kim, Analysis of single nucleotide polymorphisms of leptin gene in Hanwoo (Korean Cattle). J. Anim. Sci. & Technol (Kor.), 2007. 49(3): p. 295-302.
Cha, S.H., et al., Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease. Clin Chim Acta, 2007. 382(1-2): p. 129-33.
2006년
Shin, H.D., et al., Common promoter polymorphism in monocyte differentiation antigen CD14 is associated with serum triglyceride levels and body mass index in non-diabetic individuals. Diabet Med, 2006. 23(1): p. 72-6.
Ryu, H.J., et al., Gene-based single nucleotide polymorphisms and linkage disequilibrium patterns of 29 asthma candidate genes in the chromosome 5q31-33 region in Koreans. Int Arch Allergy Immunol, 2006. 139(3): p. 209-16.
Park, M.H., et al., Korean BAC library construction and characterization of HLA-DRA, HLA-DRB3. J Biochem Mol Biol, 2006. 39(4): p. 418-25.
Park, K.S., et al., Polymorphisms in the leptin receptor (LEPR)--putative association with obesity and T2DM. J Hum Genet, 2006. 51(2): p. 85-91.
Park, K.S., et al., Putative association of peroxisome proliferator-activated receptor gamma co-activator 1beta (PPARGC1B) polymorphism with Type 2 diabetes mellitus. Diabet Med, 2006. 23(6): p. 635-42.
Koh, J.M., et al., Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women. J Hum Genet, 2006. 51(2): p. 112-7.
Kim, K.J., et al., SNP identification, linkage disequilibrium, and haplotype analysis for a 200-kb genomic region in a Korean population. Genomics, 2006. 88(5): p. 535-40.
Hwang, J.Y., et al., Association of PLXNA2 polymorphisms with vertebral fracture risk and bone mineral density in postmenopausal Korean population. Osteoporos Int, 2006. 17(11): p. 1592-601.
Cheong, H.S., et al., Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts. J Hum Genet, 2006. 51(9): p. 781-7.
Akagawa, H., et al., A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms. Hum Mol Genet, 2006. 15(10): p. 1722-34.
2005년
Park, K.S., et al., Genetic polymorphisms in the transforming growth factor beta-induced gene associated with BMI. Hum Mutat, 2005. 25(3): p. 322.
Lee, H.J., et al., Single-nucleotide polymorphisms and haplotype LD analysis of the 29-kb IGF2 region on chromosome 11p15.5 in the Korean population. Hum Hered, 2005. 60(2): p. 73-80.
Kim, J.J., et al., Large-scale identification and characterization of genetic variants in asthma candidate genes. Immunogenetics, 2005. 57(9): p. 636-43.
Cheong, H.S., et al., CXCR3 polymorphisms associated with risk of asthma. Biochem Biophys Res Commun, 2005. 334(4): p. 1219-25.
2004년
Kim, E., et al., Identification of a novel HLA-DRB1*12 allele (DRB1*1210) in the Korean population. Tissue Antigens, 2004. 64(4): p. 518-9.
2002년
Ogata, M., et al., The prototype of sex chromosomes found in Korean populations of Rana rugosa. Cytogenet Genome Res, 2002. 99(1-4): p. 185-93.
2000년
Lee, J.Y., I.I. Hirono, and T. Aoki, Stable Expression of a Foreign Gene, Delivered by Gene Gun, in the Muscle of Rainbow Trout Oncorhynchus mykiss. Mar Biotechnol (NY), 2000. 2(3): p. 254-258.
Lee, J.Y., I. Hirono, and T. Aoki, Cloning and analysis of expression of Mx cDNA in Japanese flounder, Paralichthys olivaceus. Dev Comp Immunol, 2000. 24(4): p. 407-15.
1998년
Lee, J.Y., et al., Molecular cloning and evolution of transferrin cDNAs in salmonids. Mol Mar Biol Biotechnol, 1998. 7(4): p. 287-93.
Lee, J.H., et al., Isolation and sequence analysis of metalloprotease gene from Vibrio mimicus. Biochim Biophys Acta, 1998. 1384(1): p. 1-6.
1997년
Tange, N., et al., Cloning and characterization of transferrin cDNA and rapid detection of transferrin gene polymorphism in rainbow trout (Oncorhynchus mykiss). Mol Mar Biol Biotechnol, 1997. 6(4): p. 351-6.
Kim, G.T., et al., Nucleotide sequence of the vmhA gene encoding hemolysin from Vibrio mimicus. Biochim Biophys Acta, 1997. 1360(2): p. 102-4.
주요 실적
| 순번 | 과제명 | 연구 개요 | 기간 | 담당 업무 |
|---|---|---|---|---|
| 1 | 미진단 희귀 유전성 심근병증 메틸레이션 데이터 생산 | SureSelect Human Methyl-Seq Sequencing 방법으로 유전성 심근병증 환자에서 특이적으로 나타나는 유전자의 DNA 메틸화 패턴 발굴 | 2024.06-2024.10 | 연구책임자 |
| 2 | 계분함유 비료사용 농산물과 사용자간 항생제 내성균 전파 연구 | 농장 종사자 분변, 계분 비료 및 농작물로부터 샘플링 후, 샘플에 포함된 미생물 유전체 분석을 통하여 균 및 항생제 저항성 유전자 발굴 | 2024.05-2026.12 | 세부책임자 |
| 3 | SFTS 바이러스 감염 조직에서의 단일세포 전사체 분석 | SFTS 바이러스 유전자 변이에 따른 면역세포의 분포도 및 단일 세포 전사체 비교 분석 | 2023.10-2023.12 | 연구책임자 |
| 4 | 마이코박테리아균의 전사체 분석 서비스 | 항결핵제 처리 전후에 각각 분리한 마이코박테리아균을 대상으로 전사체 염기서열 생산 및 유전자 발현 비교 분석 | 2023.09-2023.12 | 연구책임자 |
| 5 | NGS 분석을 활용한 키르키스스탄 참진드기 내 병원체 조사 | NGS Amplicon sequencing 방식을 통한 16S rRNA 및 18S rRNA 유전자 부위 증폭 및 염기서열 확보 | 2023.09-2023.12 | 연구책임자 |
| 6 | 백신후보주 분석을 위한 병원체 전장유전체 확보 | 병원성 미생물 배양, 핵산 추출 및 전장유전체 시퀀싱 분석 | 2023.09-2023.12 | 연구책임자 |
| 7 | 카바페넴내성 아시네토박터균의 전장유전체분석 | 카바페넴내성 아시네토박터 바우마니균 22주 전장유전체 염기서열( WGS) 데이터 생산 및 분석 | 2023.08-2023.12 | 연구책임자 |
| 8 | LMO 도입유전자 및 전장유전체 데이터 생산 용역 | 환경 유전체 데이터 생산 및 바이오인포매틱 분석 | 2023.08-2023.11 | 연구책임자 |
| 9 | 국가병원체자원은행 보유 병원성 미생물의 비교유전체 분석 | 병원성 미생물의 전장유전체 시퀀싱 분석 및 유전체 비교분석 | 2023.07-2023.11 | 연구책임자 |
| 10 | 코로나19 임상검체에서의 유전체 발현 분석 | COVID-19 환자의 가래, 혈액으로부터 RNA sequencing을 통한 전사체 분석 | 2022.12-2023.06 | 연구책임자 |
| 11 | 코로나19 초중증 환자 검체 전사체 분석 | COVID-19 중증 환자의 가래, 혈액으로부터 RNA sequencing을 통한 전사체 분석 | 2022.12-2023.06 | 연구책임자 |
| 12 | 발열환자 혈장검체의 cell free DNA를 이용한 전장유전체분석 서비스 | 발열환자의 혈장 cell free DNA를 대상으로 NGS 라이브러리 제작 및 NGS 시퀀싱 후, 원인 미생물 시퀀스 발굴 (쯔쯔가무시 등) | 2022.11-2022.12 | 연구책임자 |
| 13 | 코로나19 바이러스의 범유전체 및 에피토프 분석 | 2022년까지 보고된 모든 COVID-19 염기서열을 기반으로 T-cell 및 B-cell epitope in silico prediction | 2022.07-2023.04 | 연구책임자 |
| 14 | 희귀질환 인체자원을 활용한 임상 및 오믹스 데이터 생산 | 면역성 희귀질환자의 HLA 11개 유전자에 대한 genotyping 데이터 생산 | 2022.05-2023.01 | 연구책임자 |
| 15 | 유전성망막병증 돌연변이 조기 진단 패널 개발 | 유전성망막 희귀질환 트리오 가계의 WES 데이터를 이용한 유전성 돌연변이 발굴 연구 | 2020.12-2021.12 | 연구책임자 |
| 16 | 경도인지장애 기능성 돌연변이 발굴 및 진단 컨턴츠 개발 | 경도인지장애 및 정상군 WES 데이터 분석을 통한 rare and common variant 분석 | 2019.11-2022.12 | 연구책임자 |
| 17 | 유전체 정보를 이용한 얼굴 영향지도 및 데이터베이스 구축 | 얼굴 사진과 WES 데이터를 이용한 연관성 분석 | 2020.04-2021.12 | 연구책임자 |